Our laboratory at the University of Minnesota Medical School focuses on the immune mechanisms controlling metabolically triggered inflammation. As obesity is closely associated with chronic inflammation, our goal is to discover the mechanisms by which the immune system regulates networks of inflammatory signaling pathways that ultimately trigger disease.
Our research is relevant to public health because obesity results in an increased risk of fatty liver disease, heart failure, coronary artery disease, type 2 diabetes, stroke, and certain types of cancer. Obesity and its complications are among the major health challenges of our time. Our projects provide a better understanding of how the immune system regulates metabolic disease and provide potential diagnostic and therapeutic targets for its prevention and treatment.